- Audiovisual Modules to Enhance Informed Consent in the ICU: A Pilot Study
November 30, 2020
CONCLUSIONS: Audiovisual modules may improve knowledge and comprehension of commonly performed ICU procedures among critically ill patients and caregivers who have no healthcare background.
- Clinical Trajectories of Acute Kidney Injury in Surgical Sepsis: A Prospective Observational Study
November 16, 2020
CONCLUSIONS: Among critically ill surgical sepsis patients, persistent AKI and the absence of renal recovery are associated with distinct early and sustained immunologic and endothelial biomarker...
- Extended vertical lists for temporal pattern mining from multivariate time series
November 9, 2020
In this paper, the problem of mining complex temporal patterns in the context of multivariate time series is considered. A new method called the Fast Temporal Pattern Mining with Extended Vertical...
- Publisher Correction: COVID-19-associated acute kidney injury: consensus report of the 25<sup>th</sup> Acute Disease Quality Initiative (ADQI) Workgroup
November 3, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
- Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis
November 3, 2020
Historically, murine models of inflammation in biomedical research have been shown to minimally correlate with genomic expression patterns from blood leukocytes in humans. In 2019, our laboratory...
- Mysteries, Epistemological Modesty, and Artificial Intelligence in Surgery
October 29, 2020
Life is filled with puzzles and mysteries, and we often fail to recognize the difference. As described by Gregory Treverton and Malcolm Gladwell, puzzles are solved by gathering and assimilating all...
- Virtual Reality and Human Consciousness: The Use of Immersive Environments in Delirium Therapy
October 21, 2020
Immersive virtual environments can produce a state of behavior referred to as "presence," during which the individual responds to the virtual environment as if it were real. Presence can be arranged...
- COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup
October 16, 2020
Kidney involvement in patients with coronavirus disease 2019 (COVID-19) is common, and can range from the presence of proteinuria and haematuria to acute kidney injury (AKI) requiring renal...
- Discovery and Validation of Urinary Molecular Signature of Early Sepsis
October 16, 2020
CONCLUSIONS: We identified unique urinary gene expression profile in early sepsis. Future studies need to confirm whether this approach can complement blood transcriptomic approaches for sepsis...
- Automated Detection of Rest Disruptions in Critically Ill Patients
October 6, 2020
Sleep has been shown to be an indispensable and important component of patients' recovery process. Nonetheless, the sleep quality of patients in the Intensive Care Unit (ICU) is often low, due to...
- Pain and Physical Activity Association in Critically Ill Patients<sup></sup>
October 6, 2020
Critical care patients experience varying levels of pain during their stay in the intensive care unit, often requiring administration of analgesics and sedation. Such medications generally exacerbate...
- Single Cell RNA-SEQ of Human Myeloid Derived Suppressor Cells in Late Sepsis Reveals Multiple Subsets with Unique Transcriptional Responses: A Pilot Study
October 6, 2020
CONCLUSION: This pilot study successfully demonstrated that MDSCs maintain a transcriptomic profile that is immunosuppressive in late sepsis. Interestingly, the landscape in chronic critical illness...
- Joint Distribution and Transitions of Pain and Activity in Critically Ill Patients
October 6, 2020
Pain and physical function are both essential indices of recovery in critically ill patients in the Intensive Care Units (ICU). Simultaneous monitoring of pain intensity and patient activity can be...
- Contemporary Management of Severe Acute Kidney Injury and Refractory Cardiorenal Syndrome: JACC Council Perspectives
August 29, 2020
Acute kidney injury (AKI) and cardiorenal syndrome (CRS) are increasingly prevalent in hospitalized patients with cardiovascular disease and remain associated with poor short- and long-term outcomes....
- Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference
July 26, 2020
In 2012, Kidney Disease: Improving Global Outcomes (KDIGO) published a guideline on the classification and management of acute kidney injury (AKI). The guideline was derived from evidence available...
- Improving the Intensive Care Patient Experience With Virtual Reality-A Feasibility Study
July 23, 2020
CONCLUSIONS: The use of meditative virtual reality technology in the ICU was easily implemented and well-received by patients.
- Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury
July 16, 2020
CONCLUSIONS: Among critically ill patients with acute kidney injury, an accelerated renal-replacement strategy was not associated with a lower risk of death at 90 days than a standard strategy....
- Quality of care after AKI development in the hospital: Consensus from the 22nd Acute Disease Quality Initiative (ADQI) conference
July 4, 2020
CONCLUSIONS: These recommendations identified and outlined an approach to define and evaluate the quality of AKI management in hospitalized patients.
- Decision analysis and reinforcement learning in surgical decision-making
June 17, 2020
CONCLUSION: Traditional decision-support tools are ill-equipped to accommodate time constraints and uncertainty regarding diagnoses and the predicted response to treatment, both of which often impair...
- Added Value of Intraoperative Data for Predicting Postoperative Complications: The MySurgeryRisk PostOp Extension
June 13, 2020
CONCLUSIONS: Incorporating both preoperative and intraoperative data significantly increased the accuracy, discrimination, and precision of machine learning models predicting postoperative...
- Metabolomic Profiling for Diagnosis and Prognostication in Surgery: A Scoping Review
June 3, 2020
CONCLUSIONS: Metabolomic profiling research would benefit from standardization of study design and analytic approaches. As technologies improve and knowledge garnered from research accumulates,...
- Reactive Artificial Intelligence Using Big Data in the Era of Precision Medicine-Reply
May 7, 2020
- Intelligent, Autonomous Machines in Surgery
April 28, 2020
Surgeons perform two primary tasks: operating and engaging patients and caregivers in shared decision-making. Human dexterity and decision-making are biologically limited. Intelligent, autonomous...
- Role of Wearable Accelerometer Devices in Delirium Studies: A Systematic Review
March 14, 2020
CONCLUSIONS: The results from the studies using accelerometer devices in studying delirium demonstrate that accelerometer devices can potentially detect the differences between delirious and...
- Opportunities for machine learning to improve surgical ward safety
March 5, 2020
CONCLUSIONS: Only 15-20% of patients suffering ward arrest survive. In most cases, subtle signs of instability often occur prior to critical illness and arrest, and underlying pathology is reversible....
- Identification and validation of biomarkers of persistent acute kidney injury: the RUBY study
February 7, 2020
CONCLUSION: Elevated urinary CCL14 predicts persistent AKI in a large heterogeneous cohort of critically ill patients with severe AKI. The discovery of CCL14 as a predictor of persistent AKI and thus,...
- Artificial intelligence approaches to improve kidney care
December 25, 2019
Artificial intelligence is increasingly being used to improve diagnosis and prognostication for acute and chronic kidney diseases. Studies published in 2019 relied on a variety of available data...
- Delayed interhospital transfer of critically ill patients with surgical sepsis
December 20, 2019
CONCLUSION: Patients with surgical sepsis who spent more than 24 hours at an outside facility prior to transfer had greater initial illness severity, longer intervals between admission and source...
- Artificial Intelligence and Surgical Decision-making
December 12, 2019
CONCLUSIONS AND RELEVANCE: Integration of artificial intelligence with surgical decision-making has the potential to transform care by augmenting the decision to operate, informed consent process,...
- External Validation of the qSOFA Score in Emergency Department Patients With Pneumonia
November 19, 2019
CONCLUSIONS: In this multicenter observational study of ED patients hospitalized with pneumonia, we found no significant differences between qSOFA and SIRS for predicting in-hospital death. In...
- Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis
November 15, 2019
CONCLUSIONS: We conclude that in sepsis survivors, immature myeloid cell numbers are increased but the immune suppressive function specific to MDSCs develops over time, and this is associated with a...
- Serial Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor-Binding Protein 7 and the Prognosis for Acute Kidney Injury over the Course of Critical Illness
October 17, 2019
CONCLUSION: Serial urinary [TIMP-2] × [IGFBP7] at baseline, 12 and 24 h, and up through 3 days are prognostic for the occurrence of stage 2/3 AKI over the course of critical illness. Three...
- Artificial intelligence to predict AKI: is it a breakthrough?
September 12, 2019
A new study of deep learning based on electronic health records promises to forecast acute kidney injury up to 48 hours before it can be diagnosed clinically. However, employing data science to...
- Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model
August 8, 2019
CONCLUSIONS: The results indicate that this murine cecal ligation and puncture + daily chronic stress model of surgical sepsis in old mice adhered to current Minimum Quality Threshold in Pre-Clinical...
- Use of Artificial Intelligence to Represent Emergent Systems and Augment Surgical Decision-making
June 20, 2019
- Intelligent ICU for Autonomous Patient Monitoring Using Pervasive Sensing and Deep Learning
May 31, 2019
Currently, many critical care indices are not captured automatically at a granular level, rather are repetitively assessed by overburdened nurses. In this pilot study, we examined the feasibility of...
- Quality Improvement Goals for Acute Kidney Injury
May 19, 2019
AKI is a global concern with a high incidence among patients across acute care settings. AKI is associated with significant clinical consequences and increased health care costs. Preventive measures,...
- Response to Comment on "MySurgeryRisk: Development and Validation of a Machine-learning Risk Algorithm for Major Complications and Death After Surgery"
May 15, 2019
- Improved predictive models for acute kidney injury with IDEA: Intraoperative Data Embedded Analytics
April 5, 2019
CONCLUSIONS: Postoperative AKI prediction was improved with high sensitivity and specificity through a machine learning approach that dynamically incorporated intraoperative data.
- Autonomous detection of disruptions in the intensive care unit using deep mask RCNN
April 2, 2019
Patients staying in the Intensive Care Unit (ICU) have a severely disrupted circadian rhythm. Due to patients' critical medical condition, ICU physicians and nurses have to provide round-the-clock...
- Comparing clinical judgment with the MySurgeryRisk algorithm for preoperative risk assessment: A pilot usability study
February 23, 2019
CONCLUSION: Implementation of a validated, MySurgeryRisk computational algorithm for real-time predictive analytics with data derived from the electronic health records to augment physicians'...
- DeepSOFA: A Continuous Acuity Score for Critically Ill Patients using Clinically Interpretable Deep Learning
February 14, 2019
Traditional methods for assessing illness severity and predicting in-hospital mortality among critically ill patients require time-consuming, error-prone calculations using static variable thresholds....
- The Development of Chronic Critical Illness Determines Physical Function, Quality of Life, and Long-Term Survival Among Early Survivors of Sepsis in Surgical ICUs
January 22, 2019
CONCLUSIONS: Surgical patients who develop chronic critical illness after sepsis exhibit high healthcare resource utilization and ultimately suffer dismal long-term clinical, functional, and...
- Persistent inflammation and anemia among critically ill septic patients
November 30, 2018
CONCLUSION: Persistent elevation of inflammatory cytokines was associated with iron-restricted anemia among critically ill septic patients, occurring in the absence of systemic iron deficiency,...
- Comparison of Gaussian Processes Methods to Linear methods for Imputation of Sparse Physiological Time Series
November 17, 2018
Physiological timeseries such as vital signs contain important information about a patient and are used in different clinical application; however, they suffer from missing values and sampling...
- Activity and Circadian Rhythm of Sepsis Patients in the Intensive Care Unit
November 10, 2018
Early mobilization of critically ill patients in the Intensive Care Unit (ICU) can prevent adverse outcomes such as delirium and post-discharge physical impairment. To date, no studies have...
- Delirium Prediction using Machine Learning Models on Preoperative Electronic Health Records Data
November 6, 2018
Electronic Health Records (EHR) are mainly designed to record relevant patient information during their stay in the hospital for administrative purposes. They additionally provide an efficient and...
- Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury: A Randomized Clinical Trial
October 26, 2018
CONCLUSIONS AND RELEVANCE: Among patients who were critically ill with sepsis-associated acute kidney injury, human recombinant alkaline phosphatase compared with placebo did not significantly improve...
- Intelligent Perioperative System: Towards Real-time Big Data Analytics in Surgery Risk Assessment
October 2, 2018
Surgery risk assessment is an effective tool for physicians to manage the treatment of patients, but most current research projects fall short in providing a comprehensive platform to evaluate the...
- Epidemiology, outcomes, and management of acute kidney injury in the vascular surgery patient
August 28, 2018
CONCLUSIONS: AKI is a common postoperative complication among vascular surgery patients and has a significant impact on morbidity, mortality, and cost. Preoperative risk assessment and optimal...
- Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome
July 18, 2018
Dysregulated host immune responses to infection often occur, leading to sepsis, multiple organ failure, and death. Some patients rapidly recover from sepsis, but many develop chronic critical illness...
- Deep EHR: A Survey of Recent Advances in Deep Learning Techniques for Electronic Health Record (EHR) Analysis
July 11, 2018
The past decade has seen an explosion in the amount of digital information stored in electronic health records (EHRs). While primarily designed for archiving patient information and performing...
- D.R.E.A.M.S: (Digital Rehabilitation Environment-Altering Medical System)
June 5, 2018
In project D.R.E.A.M.S., we propose to develop and assess the feasibility of a novel and intelligent delirium-prevention system to address depression, pain, sleep, activity patterns and emotional...
- Cardiac and Vascular Surgery-Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group
June 3, 2018
- Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery
May 30, 2018
As early as the 1990s, chronic critical illness, a distinct syndrome of persistent high-acuity illness requiring management in the ICU, was reported under a variety of descriptive terms including the...
- Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy
April 20, 2018
Clinical and technological advances promoting early hemorrhage control and physiologic resuscitation as well as early diagnosis and optimal treatment of sepsis have significantly decreased in-hospital...
- The impact of age on the innate immune response and outcomes after severe sepsis/septic shock in trauma and surgical intensive care unit patients
April 4, 2018
CONCLUSION: Aged, critically ill surgical patients have greater organ dysfunction and incidence of adverse clinical outcomes after sepsis. Biomarker profiles suggest an immunophenotype of persistent...
- Outcomes in Patients with Vasodilatory Shock and Renal Replacement Therapy Treated with Intravenous Angiotensin II
March 7, 2018
CONCLUSIONS: In patients with acute kidney injury requiring renal replacement therapy at study drug initiation, 28-day survival and mean arterial pressure response were higher, and rate of renal...
- MySurgeryRisk: Development and Validation of a Machine-learning Risk Algorithm for Major Complications and Death After Surgery
March 1, 2018
CONCLUSIONS: We constructed an automated predictive analytics framework for machine-learning algorithm with high discriminatory ability for assessing the risk of surgical complications and death using...
- Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients
December 19, 2017
CONCLUSION: The development of CCI has become the predominant clinical trajectory in critically ill surgical patients with sepsis. These patients exhibit biomarker profiles consistent with an...
- Acute kidney injury: Precision perioperative care protects the kidneys
December 14, 2017
- Guiding AKI Prevention Using Biomarkers
October 17, 2017
- The Impact of Changes in Medicare's Physician Payment System on Critical Care
September 29, 2017
In 2015 President Obama signed the Medicare Access and CHIP Reauthorization Act (MACRA) which repealed the Sustainable Growth Rate (SGR) mechanism for Medicare physician reimbursement and mandated...
- Evidence for Persistent Immune Suppression in Patients Who Develop Chronic Critical Illness After Sepsis
September 9, 2017
CONCLUSIONS: Septic patients demonstrate clinical and biological evidence to suggest they are immunosuppressed at the time of sepsis diagnosis. Those who develop CCI have a greater incidence of...
- Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients
August 3, 2017
INTRODUCTION: Sepsis is a common, costly and morbid cause of critical illness in trauma and surgical patients. Ongoing advances in sepsis resuscitation and critical care support strategies have led to...
- Kidney and Brain, an Unbroken Chain
June 16, 2017
- Angiotensin II for the Treatment of Vasodilatory Shock
May 23, 2017
CONCLUSIONS: Angiotensin II effectively increased blood pressure in patients with vasodilatory shock that did not respond to high doses of conventional vasopressors. (Funded by La Jolla Pharmaceutical...
- Perioperative Acute Kidney Injury: Risk Factors and Predictive Strategies
March 13, 2017
Acute kidney injury (AKI) is a common complication in surgical patients and is associated with increases in mortality, an increased risk for chronic kidney disease and hemodialysis after discharge,...
- Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup
February 28, 2017
Consensus definitions have been reached for both acute kidney injury (AKI) and chronic kidney disease (CKD) and these definitions are now routinely used in research and clinical practice. The KDIGO...
- Acute Kidney Injury Following Exploratory Laparotomy and Temporary Abdominal Closure
December 24, 2016
CONCLUSIONS: AKI is common following TAC, reaches greatest prevalence 48 h after initial laparotomy, and is associated with increased mortality. NPWT fluid loss is a risk factor for AKI that is unique...
- Optimal Role of the Nephrologist in the Intensive Care Unit
December 7, 2016
As advances in Critical Care Medicine continue, critically ill patients are surviving despite the severity of their illness. The incidence of acute kidney injury (AKI) has increased, and its impact on...
- Mortality and cost of acute and chronic kidney disease after cardiac surgery
November 15, 2016
PURPOSE OF REVIEW: Acute and chronic kidney diseases (AKI and CKD) have far-reaching implications for surgical patients in regards to postoperative outcomes and hospital cost. We review the recent...
- Recovery after Acute Kidney Injury
September 17, 2016
CONCLUSIONS: We have identified five distinct recovery phenotypes on the basis of the clinical course over the first week after AKI manifestation. These phenotypes may identify patients amenable to...
- Preoperative assessment of the risk for multiple complications after surgery
May 31, 2016
CONCLUSION: Readily available, preoperative clinical and sociodemographic factors are associated with a greater number of postoperative complications and adverse surgical outcomes. We developed an...
- Application of Machine Learning Techniques to High-Dimensional Clinical Data to Forecast Postoperative Complications
May 28, 2016
CONCLUSIONS: Generalized additive models and support vector machines had good performance as risk prediction model for postoperative sepsis and AKI. Feature extraction using principal component...
- Authors' reply re:Acute kidney injury in major gynaecological surgery: an observational study
May 21, 2016
- Perioperative Acute Kidney Injury-Reply
April 7, 2016
- Long-Term Outcomes for Different Forms of Stress Cardiomyopathy After Surgical Treatment for Subarachnoid Hemorrhage
March 24, 2016
CONCLUSIONS: SAH patients with echocardiogram for a clinically indicated reason have a decreased long-term survival, regardless of the presence of RLVD. The association between severe sepsis and...
- Clinical Use of the Urine Biomarker [TIMP-2] × [IGFBP7] for Acute Kidney Injury Risk Assessment
March 8, 2016
Acute kidney injury (AKI) is a serious complication, commonly occurring in the critically ill population, with devastating short- and long-term consequences. Despite standardization of the definition...
- Establishing a continuum of acute kidney injury - tracing AKI using data source linkage and long-term follow-up: Workgroup Statements from the 15th ADQI Consensus Conference
March 1, 2016
CONCLUSIONS: We have identified minimal data elements and potential data sources necessary to trace the natural history of patients from onset of AKI to long-term outcome. Minimum infrastructure and...
- TIMP2•IGFBP7 biomarker panel accurately predicts acute kidney injury in high-risk surgical patients
January 28, 2016
CONCLUSION: For postoperative surgical intensive care unit patients, a single urinary TIMP2•IGFBP7 test accurately identified patients at risk for developing AKI within the ensuing 12 hours and its...
- Acute and Chronic Kidney Disease and Cardiovascular Mortality After Major Surgery
January 13, 2016
CONCLUSIONS: Both AKI and CKD were associated with higher long-term cardiovascular-specific mortality compared with patients having no kidney disease.
- Cardiovascular-Specific Mortality and Kidney Disease in Patients Undergoing Vascular Surgery
January 1, 2016
CONCLUSIONS AND RELEVANCE: Perioperative AKI is common in patients undergoing vascular surgery and is associated with a high risk for cardiovascular-specific mortality comparable to that seen with...
- Critical Care Delivery and ICU Structure-The Elephant in the Room
November 18, 2015
- Variant Neurogenic Stunned Myocardium in a Young Female After Subarachnoid Hemorrhage
October 1, 2015
Neurogenic stunned myocardium is a significant complication of subarachnoid hemorrhage. Diagnosis of neurogenic stunned myocardium is complicated by variable presentation. We present a case of a...
- Acute Kidney Injury in the Surgical Patient
September 28, 2015
Perioperative acute kidney injury (AKI) is a common, morbid, and costly surgical complication. Current efforts to understand and manage AKI in surgical patients focus on prevention, mitigation of...
- Acute Kidney Injury in the Surgical Patient: Recognition and Attribution
September 8, 2015
Postoperative acute kidney injury (AKI) is not only one of the most common postoperative complications but is also associated with increased in-hospital mortality, decreased survival for up to 10...
- A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged
August 7, 2015
The elderly are particularly susceptible to trauma, and their outcomes are frequently dismal. Such patients often have complicated clinical courses and ultimately die of infection and sepsis. Recent...
- Outpatient Dialysis for Patients with AKI: A Policy Approach to Improving Care
July 30, 2015
The rate of AKI requiring dialysis has increased significantly over the past decade in the United States. At the same time, survival from AKI seems to be improving, and thus, more patients with AKI...
- Clostridium difficile Infections after Blunt Trauma: A Different Patient Population?
July 25, 2015
CONCLUSION: Analysis of severe blunt trauma patients with C. difficile, as compared with non-CDI patients, reveals evidence of increased inflammation, immunosuppression, worse acute kidney injury,...
- Mortality and Cost of Acute and Chronic Kidney Disease after Vascular Surgery
July 19, 2015
CONCLUSIONS: Kidney disease after major vascular surgery is associated with significant increases in 90-day mortality and cost with the highest risk observed among patients with AKI regardless of...
- The Pattern of Longitudinal Change in Serum Creatinine and 90-Day Mortality After Major Surgery
July 17, 2015
CONCLUSIONS: We demonstrate the nonlinear relationship between both severity and recovery of renal dysfunction and 90-day mortality after major surgery. We have developed an easily applicable computer...
- Promoting Kidney Function Recovery in Patients with AKI Requiring RRT
July 4, 2015
AKI requiring RRT is associated with high mortality, morbidity, and long-term consequences, including CKD and ESRD. Many patients never recover kidney function; in others, kidney function improves...
- Successful implementation of a packed red blood cell and fresh frozen plasma transfusion protocol in the surgical intensive care unit
May 27, 2015
CONCLUSIONS: Implementation of a restrictive transfusion protocol can effectively reduce blood product utilization in critically ill surgical patients with no increase in morbidity or mortality.
- Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock
April 17, 2015
CONCLUSIONS: We concluded that advanced age is one of the strongest non-injury related risk factors for poor outcomes after severe trauma with hemorrhagic shock and is associated with an altered and...
- Acute kidney injury in 2014: a step towards understanding mechanisms of renal repair
January 7, 2015
In 2014, key articles in the field of acute kidney injury highlighted the importance of tubular homeostasis in renal regeneration. Cell cycle regulators, inflammatory signals and progenitors were...
- Tissue Inhibitor Metalloproteinase-2 (TIMP-2)⋅IGF-Binding Protein-7 (IGFBP7) Levels Are Associated with Adverse Long-Term Outcomes in Patients with AKI
December 24, 2014
Tissue inhibitor metalloproteinase-2 (TIMP-2) and IGF-binding protein-7 (IGFBP7) have been validated for risk stratification in AKI. However, the association of urinary TIMP-2 and IGFBP7 with...
- Gram stain can be used to safely discontinue vancomycin therapy for early pneumonia in the trauma intensive care unit
December 17, 2014
- Insurance status is associated with treatment allocation and outcomes after subarachnoid hemorrhage
August 21, 2014
CONCLUSIONS: Nearly two thirds of patients with SAH don't receive operative care, and Medicare patients were significantly less likely to receive surgical treatment than other patients. Bias against...
- Cost and Mortality Associated With Postoperative Acute Kidney Injury
June 3, 2014
CONCLUSIONS: Hospital costs and mortality are strongly associated with postoperative AKI, are correlated with the severity of AKI, and are much higher for patients with other postoperative...