Research

innovation in medicine

Making New Discoveries

There is always exciting research being conducted at PRISMAp labs. Find out more about our exciting research or read one of our many published articles below.

someone injecting liquid into vials in a lab

Current Projects

  • Motion Analysis of Delirium in the Intensive Care Unit (ICU)
  • Intelligent ICU of the Future
  • Integrating Data, Algorithms and Clinical Reasoning for Surgical Risk Assessment (IDEALIST)
  • Automated Algorithm Identifies and Communicates Risk of Acute Kidney Injury among Health Care Providers and Patients (AKI-EPIC)
  • Network Analysis of Urinary Molecular Signature Complements Clinical Data to Predict Postoperative Acute Kidney Injury (NavigateAKI) clinicaltrials.gov
  • Digital Rehabilitation Environment Augmenting Medical System (DREAMS) clinicaltrials.gov

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Featured Publications

Human Activity Recognition Using Inertial, Physiological, and Environmental Sensors

This survey focuses on critical role of machine learning in developing Human Activity Recognition applications based on inertial sensors in conjunction with physiological and environmental sensors.

diagram showing a person with a walker

Discovery and Validation of Urinary Molecular Signature of Early Sepsis

The first ever study to use urinary cellular gene expression to study sepsis. Researchers identified alterations in gene expression unique to systemic and kidney-specific pathophysiologic processes using whole-genome analyses of RNA isolated from the urinary cells of sepsis patients.

diagram of kidney

Clinical Trajectories of Acute Kidney Injury in Surgical Sepsis: A Prospective Observational Study 

Among critically ill surgical sepsis patients, persistent AKI and the absence of renal recovery are associated with distinct early and sustained immunologic and endothelial biomarker signatures and decreased long-term physical function and survival.

graph showing survival probability versus months after sepsis onset

Audiovisual Modules to Enhance Informed Consent in the ICU: A Pilot Study

Audiovisual modules may improve knowledge and comprehension of commonly performed ICU procedures among critically ill patients and caregivers who have no healthcare background.

Critical Care Explorations journal cover

Extended vertical lists for temporal pattern mining from multivariate time series

In this paper, the problem of mining complex temporal patterns in the context of multivariate time series is considered. A new method called the Fast Temporal Pattern Mining with Extended Vertical Lists.

graph showing pattern length versus computational time

Reinforcement learning in surgery

Patients and physicians make essential decisions regarding diagnostic and therapeutic interventions. These actions should be performed or deferred under time constraints and uncertainty regarding patients’ diagnoses and predicted response to treatment. This may lead to cognitive and judgment errors.

diagram showing reinforcement learning framework and challenges in development of reinforcement learning models

Our Latest Publications

Postoperative acute kidney injury in adult non-cardiac surgery: joint consensus report of the Acute Disease Quality Initiative and PeriOperative Quality Initiative

Postoperative acute kidney injury (PO-AKI) is a common complication of major surgery that is strongly associated with short-term surgical complications and long-term adverse outcomes, including increased risk of chronic kidney…

Intraoperative hypotension and complications after vascular surgery: A scoping review

CONCLUSION: There is no validated, consensus definition of intraoperative hypotension or other hemodynamic parameters associated with increased risk for adverse outcomes. Despite these limitations, the weight of evidence suggests that…

Cardiovascular and Renal Disease in Chronic Critical Illness

With advances in critical care, patients who would have succumbed in previous eras now survive through hospital discharge. Many survivors suffer from chronic organ dysfunction and induced frailty, representing an…

Development of a Theory-Informed Behavior Change Intervention to Reduce Inappropriate Prescribing of Nephrotoxins and Renally Eliminated Drugs

CONCLUSIONS AND RELEVANCE: Assigning a designated clinician to execute a stepwise, routine care process following the checklist provided is a recommended intervention to overcome barriers. The intended impact is behavior…