innovation in medicine
Making New Discoveries
There’s always groundbreaking research happening at PRISMAp Labs, where we push the boundaries of innovation in multi-omics and computational biology. Explore our latest projects, discover how our work is shaping the future of healthcare, or dive into our extensive collection of published articles below.

Current Projects

ADAPT
Autonomous Delirium Monitoring and Adaptive Prevention
Delirium prevention in the ICU is often achieved with non-pharmacological approaches, but some methods are difficult to implement due to their dependence on sporadic human observations. ADAPT, the Autonomous Delirium Monitoring and Adaptive Prevention system, will autonomously quantify two indicators of delirium (patient mobility and circadian desynchrony) and predict delirium trajectories, as well as prompt actions that decrease delirium risk factors (e.g., ambient light, nightly disruptions). Successful application of ADAPT would augment clinical decision-making and promote more targeted interventions.

CHORUS (BRIDGE2AI)
A Patient-Focused Collaborative Hospital Repository Using Standards (CHoRUS) for AI
While AI in critical care (AICC) has helped improve patient care, AICC research lacks a large generalized dataset, standards that support the exchange and use of health information (interoperability) between sites and researchers, and support from a workforce trained in AI and general public familiar with medical AI. CHoRUS, a multimillion dollar collaboration of 18 top medical research institutions, aims to solve these problems by creating a 100,000 patient dataset from a sample population with varied backgrounds, ethical standards that enable interoperability, and AI education for AICC researchers and the general public.

Intelligent Intensive Care Unit (I2CU)
Pervasive Sensing and Artificial Intelligence for Augmented Clinical Decision-Making
Although close monitoring and dynamic assessment of patient acuity are key aspects of ICU care, both are limited by time constraints imposed on healthcare providers. Dynamic and precise assessment of patient acuity relies almost exclusively on physicians’ clinical judgement and vigilance, and details indicating patient condition may be partially captured or completely missed by overburdened nurses. We aim to develop deep learning models for sensing, quantifying, and communicating any patient’s condition in an autonomous, precise, and interpretable manner. This tool could enhance clinical workflow and enable early intervention.

idealist
Integrating Data, Algorithms, and Clinical Reasoning for Surgical Risk Assessment
IDEALIST could advance the ability of healthcare providers to diagnose diseases by computing the risk of postoperative complications in real-time. Ultimately, the results are expected to improve patient outcomes, decrease hospitalization costs, and reduce lifelong complications. The proposed research is relevant to public health because it can result in enhanced perioperative care workflow and early intervention.

MEND-AKI
Multi-Hospital Electronic Decision Support for Drug-Associated AKI
The Multi-Hospital Electronic Decision Support for Drug-Associated AKI (MEnD-AKI) project is aimed at assessing how effective a clinical surveillance system augmented with real-time predictive analytics can be in supporting pharmacist-led interventions to address drug-associated AKI (D-AKI).

AI Passport
Artificial Intelligence Passport for Biomedical Research
Al Passport for Biomedical Research addresses the unique needs of a biomedical, behavioral, and clinical research workforce that has no previous training in Al. In addition to providing a foundational understanding of AI concepts and teaching AI skills, we train participants in its ethical and responsible use. Trustworthy AI is interdisciplinary. Our unique digital community transcends traditional boundaries, ensuring that Al Passport for Health’s educational experience prepares participants for a future where innovation meets impact. We foster a collaborative, open, and communicative environment, ensuring that participant insights contribute directly to the learning experience.

JAX Dt
Health, Housing and Hazards Digital Twin for the City of Jacksonville: A Pilot of Florida’s Digital Twin
In January 2024, the University of Florida, Deloitte and NVIDIA joined forces to build JaxTwin, an advanced urban digital twin (UDT). This innovative tool will equip leaders with the ability to plan adaptation measures that will ensure the future health, resilience and economic vitality of Jacksonville’s residents.

HOSPITAL DT
Towards Health Metaverse: AI Enabled Intelligent Virtual Hospital (I2VH)
Intelligent Hospital Digital Twin is an AI-powered, intelligent virtual ICU that represents the next step toward a health metaverse. By integrating real-time clinical data, predictive analytics, and machine learning, the technology simulates hospital environments, optimizes decision-making, and improves outcomes in critical care.

EXPOSOME database
Exposome Database
The Exposome Database is a comprehensive repository that compiles a wide range of data related to the social, economic, and environmental factors affecting health outcomes of populations. This database is crucial for public health research, policy-making, and interventions aimed at improving health and overall well-being.
Additional Projects
- Network Analysis of Urinary Molecular Signature Complements Clinical Data to Predict Postoperative Acute Kidney Injury (NavigateAKI) clinicaltrials.gov
- Digital Rehabilitation Environment Augmenting Medical System (DREAMS) clinicaltrials.gov
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Featured Publications
Human activity recognition using inertial, physiological, and environmental sensors
This survey focuses on critical role of machine learning in developing Human Activity Recognition applications based on inertial sensors in conjunction with physiological and environmental sensors.

Discovery and validation of urinary molecular signature of early sepsis
The first ever study to use urinary cellular gene expression to study sepsis. Researchers identified alterations in gene expression unique to systemic and kidney-specific pathophysiologic processes using whole-genome analyses of RNA isolated from the urinary cells of sepsis patients.

Clinical trajectories of acute kidney injury in surgical sepsis: a prospective observational study
Among critically ill surgical sepsis patients, persistent AKI and the absence of renal recovery are associated with distinct early and sustained immunologic and endothelial biomarker signatures and decreased long-term physical function and survival.

Audiovisual modules to enhance informed consent in the ICU: a pilot study
Audiovisual modules may improve knowledge and comprehension of commonly performed ICU procedures among critically ill patients and caregivers who have no healthcare background.

Extended vertical lists for temporal pattern mining from multivariate time series
In this paper, the problem of mining complex temporal patterns in the context of multivariate time series is considered. A new method called the Fast Temporal Pattern Mining with Extended Vertical Lists.

Reinforcement learning in surgery
Patients and physicians make essential decisions regarding diagnostic and therapeutic interventions. These actions should be performed or deferred under time constraints and uncertainty regarding patients’ diagnoses and predicted response to treatment. This may lead to cognitive and judgment errors.

Our Latest Publications
Building health systems capable of leveraging AI: applying Paul Farmer's 5S framework for equitable global health
The development of artificial intelligence (AI) applications in healthcare is often positioned as a solution to the greatest challenges facing global health. Advocates propose that AI can bridge gaps in…
Honoring Advance Directives: A Scoping Review of Adherence and Impact on Value of Care
Introduction: End-of-life clinical decision making can trigger profound emotional and financial distress. Advance directives intend to guide clinicians and surrogate decision makers; it is difficult to know how often they…
Epidemiology, trajectories and outcomes of acute kidney injury among hospitalized patients: a large retrospective multicenter cohort study
CONCLUSIONS: Persistent AKI was associated with prolonged hospitalization, increased ICU admission and greater mortality compared to the other groups. This may emphasize the critical need for devising strategies targeting effective…